All mouse strains and reagents that have been described in publications will be provided on a non-collaborative basis. All mouse strains currently available, as well as mouse strains anticipated to be available in the near future, are listed below.

Please note:

  • All materials will be provided free-of-charge; however, investigators requesting mice will be required to pay shipping costs.
  • All investigators will be required to complete a Material Transfer Agreement. Please note that the primary restrictions are that materials may not be used for commercial purposes and that materials may not be distributed to a third party without prior consent of Se-Jin Lee.
  • Requests for DNA clones will ordinarily be processed in 1-3 days.
  • Requests for mice will be filled in the order received. Depending on the time required to complete the paperwork and depending on the availability of the requested mice, the entire process usually takes approximately 1-3 months.
  • To initiate a request, please complete the request form below.
Strain Description Reference Availability
Mstn (Gdf8) knockout deletion of C-terminal domain Alexandra C. McPherron, Ann M. Lawler, and Se-Jin Lee (1997) Regulation of skeletal muscle mass in mice by a new TGF-ß superfamily member. Nature 387:83-90 available
Gdf11 knockout deletion of C-terminal domain Alexandra C. McPherron, Ann M. Lawler, and Se-Jin Lee (1999) Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor-11. Nature Genet. 22:260-264 available
Gdf10 knockout deletion of C-terminal domain Renbin Zhao, Ann M. Lawler, and Se-Jin Lee (1999) Characterization of GDF-10 expression patterns and null mice. Dev. Biol. 212:68-79 available
Gdf1 knockout deletion of C-terminal domain Christopher T. Rankin, Tracie Bunton, Ann M. Lawler, and Se-Jin Lee (2000) Regulation of left-right patterning in mice by growth/differentiation factor-1. Nature Genet. 24:262-265
Gdf15 knockout deletion of C-terminal domain Edward C. Hsiao, Leonidas G. Koniaris, Teresa A. Zimmers-Koniaris, Suzanne M. Sebald, Thanh Huynh, and Se-Jin Lee (2000) Characterization of growth/differentiation factor-15 (Gdf15): a TGF-ß superfamily member induced following liver injury. Mol. Cell. Bi available
mdx/Mstn knockout deletion of Mstn C-terminal domain on mdx background Kathryn R. Wagner, Alexandra C. McPherron, Nicole Winik, and Se-Jin Lee (2002) Loss of myostatin attenuates severity of muscular dystrophy in mdx mice. Ann. Neurol. 52:832-836 available
MLC/myostatin propeptide transgenic myosin light chain promoter/enhancer Se-Jin Lee and Alexandra C. McPherron (2001) Regulation of myostatin activity and muscle growth. Proc. Natl. Acad. Sci., USA 98:9306-9311 available
MLC/follistatin transgenic myosin light chain promoter/enhancer Se-Jin Lee and Alexandra C. McPherron (2001) Regulation of myostatin activity and muscle growth. Proc. Natl. Acad. Sci., USA 98:9306-9311 available
MLC/dominant negative Acvr2b transgenic myosin light chain promoter/enhancer Se-Jin Lee and Alexandra C. McPherron (2001) Regulation of myostatin activity and muscle growth. Proc. Natl. Acad. Sci., USA 98:9306-9311 available
MLC/Flrg transgenic myosin light chain promoter/enhancer Se-Jin Lee (2007) Quadrupling muscle mass in mice by targeting TGF-ß signaling pathways. PLoS ONE 2(8):e789. doi:10.1371/journal.pone.0000789 available
Flrg (Fstl3)-flox Se-Jin Lee, Yun-Sil Lee, Teresa A. Zimmers, Arshia Soleimani, Martin M. Matzuk, Kunihiro Tsuchida, Ronald D. Cohn, and Elisabeth R. Barton (2010) Regulation of muscle mass by follistatin and activins. Mol. Endocrinol.24:1998-2008 available
Flrg (Fstl3) deletion Se-Jin Lee, Yun-Sil Lee, Teresa A. Zimmers, Arshia Soleimani, Martin M. Matzuk, Kunihiro Tsuchida, Ronald D. Cohn, and Elisabeth R. Barton (2010) Regulation of muscle mass by follistatin and activins. Mol. Endocrinol.24:1998-2008 available
MLC/cre myosin light chain promoter/enhancer Alexandra C. McPherron, Thanh V. Huynh, and Se-Jin Lee (2009) Redundancy of myostatin and growth/differentiation factor 11 function. BMC Dev. Biol. 9:24. doi:10.1186/1471-213X-9-24. available
Gdf11-flox Alexandra C. McPherron, Thanh V. Huynh, and Se-Jin Lee (2009) Redundancy of myostatin and growth/differentiation factor 11 function. BMC Dev. Biol. 9:24. doi:10.1186/1471-213X-9-24. available
Mstn D76A point mutation rendering the propeptide protease-resistant Se-Jin Lee (2008) Genetic analysis of the role of proteolysis in the activation of latent myostatin. PLoS ONE 3(8):e1628. doi:10.1371/journal.pone.0001628 available
Tll2 knockout deletion of exon 7 Se-Jin Lee (2008) Genetic analysis of the role of proteolysis in the activation of latent myostatin. PLoS ONE 3(8):e1628. doi:10.1371/journal.pone.0001628 available
Tll1 knockout unpublished pending publication
Tll1-flox unpublished pending publication
Bmp1 knockout unpublished pending publication
Bmp1-flox unpublished pending publication
Mstn-flox unpublished pending publication
Smad2-flox unpublished pending publication
Bmp9 (Gdf2) knockout deletion of C-terminal domain unpublished pending publication
Inhbc knockout deletion of C-terminal domain unpublished pending publication
Inhbe (Gdf12) knockout deletion of C-terminal domain unpublished pending publication
Inhbc/Inhbedouble knockout deletion of entire Inhbc/Inhbelocus Se-Jin Lee, Yun-Sil Lee, Teresa A. Zimmers, Arshia Soleimani, Martin M. Matzuk, Kunihiro Tsuchida, Ronald D. Cohn, and Elisabeth R. Barton (2010) Regulation of muscle mass by follistatin and activins. Mol. Endocrinol.24:1998-2008 available
MLC/rtTA MLC/tetR-KRAB myosin light chain promoter/enhancer unpublished pending publication

Request Form

Requesting Investigator

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