All mouse strains and reagents that have been described in publications will be provided on a non-collaborative basis. All mouse strains currently available, as well as mouse strains anticipated to be available in the near future, are listed below.
Please note:
- All materials will be provided free-of-charge; however, investigators requesting mice will be required to pay shipping costs.
- All investigators will be required to complete a Material Transfer Agreement. Please note that the primary restrictions are that materials may not be used for commercial purposes and that materials may not be distributed to a third party without prior consent of Se-Jin Lee.
- Requests for DNA clones will ordinarily be processed in 1-3 days.
- Requests for mice will be filled in the order received. Depending on the time required to complete the paperwork and depending on the availability of the requested mice, the entire process usually takes approximately 1-3 months.
- To initiate a request, please complete the request form below.
| Strain | Description | Reference | Availability |
| Mstn (Gdf8) knockout | deletion of C-terminal domain | Alexandra C. McPherron, Ann M. Lawler, and Se-Jin Lee (1997) Regulation of skeletal muscle mass in mice by a new TGF-ß superfamily member. Nature 387:83-90 | available |
| Gdf11 knockout | deletion of C-terminal domain | Alexandra C. McPherron, Ann M. Lawler, and Se-Jin Lee (1999) Regulation of anterior/posterior patterning of the axial skeleton by growth/differentiation factor-11. Nature Genet. 22:260-264 | available |
| Gdf10 knockout | deletion of C-terminal domain | Renbin Zhao, Ann M. Lawler, and Se-Jin Lee (1999) Characterization of GDF-10 expression patterns and null mice. Dev. Biol. 212:68-79 | available |
| Gdf1 knockout | deletion of C-terminal domain | Christopher T. Rankin, Tracie Bunton, Ann M. Lawler, and Se-Jin Lee (2000) Regulation of left-right patterning in mice by growth/differentiation factor-1. Nature Genet. 24:262-265 | |
| Gdf15 knockout | deletion of C-terminal domain | Edward C. Hsiao, Leonidas G. Koniaris, Teresa A. Zimmers-Koniaris, Suzanne M. Sebald, Thanh Huynh, and Se-Jin Lee (2000) Characterization of growth/differentiation factor-15 (Gdf15): a TGF-ß superfamily member induced following liver injury. Mol. Cell. Bi | available |
| mdx/Mstn knockout | deletion of Mstn C-terminal domain on mdx background | Kathryn R. Wagner, Alexandra C. McPherron, Nicole Winik, and Se-Jin Lee (2002) Loss of myostatin attenuates severity of muscular dystrophy in mdx mice. Ann. Neurol. 52:832-836 | available |
| MLC/myostatin propeptide transgenic | myosin light chain promoter/enhancer | Se-Jin Lee and Alexandra C. McPherron (2001) Regulation of myostatin activity and muscle growth. Proc. Natl. Acad. Sci., USA 98:9306-9311 | available |
| MLC/follistatin transgenic | myosin light chain promoter/enhancer | Se-Jin Lee and Alexandra C. McPherron (2001) Regulation of myostatin activity and muscle growth. Proc. Natl. Acad. Sci., USA 98:9306-9311 | available |
| MLC/dominant negative Acvr2b transgenic | myosin light chain promoter/enhancer | Se-Jin Lee and Alexandra C. McPherron (2001) Regulation of myostatin activity and muscle growth. Proc. Natl. Acad. Sci., USA 98:9306-9311 | available |
| MLC/Flrg transgenic | myosin light chain promoter/enhancer | Se-Jin Lee (2007) Quadrupling muscle mass in mice by targeting TGF-ß signaling pathways. PLoS ONE 2(8):e789. doi:10.1371/journal.pone.0000789 | available |
| Flrg (Fstl3)-flox | Se-Jin Lee, Yun-Sil Lee, Teresa A. Zimmers, Arshia Soleimani, Martin M. Matzuk, Kunihiro Tsuchida, Ronald D. Cohn, and Elisabeth R. Barton (2010) Regulation of muscle mass by follistatin and activins. Mol. Endocrinol.24:1998-2008 | available | |
| Flrg (Fstl3) deletion | Se-Jin Lee, Yun-Sil Lee, Teresa A. Zimmers, Arshia Soleimani, Martin M. Matzuk, Kunihiro Tsuchida, Ronald D. Cohn, and Elisabeth R. Barton (2010) Regulation of muscle mass by follistatin and activins. Mol. Endocrinol.24:1998-2008 | available | |
| MLC/cre | myosin light chain promoter/enhancer | Alexandra C. McPherron, Thanh V. Huynh, and Se-Jin Lee (2009) Redundancy of myostatin and growth/differentiation factor 11 function. BMC Dev. Biol. 9:24. doi:10.1186/1471-213X-9-24. | available |
| Gdf11-flox | Alexandra C. McPherron, Thanh V. Huynh, and Se-Jin Lee (2009) Redundancy of myostatin and growth/differentiation factor 11 function. BMC Dev. Biol. 9:24. doi:10.1186/1471-213X-9-24. | available | |
| Mstn D76A | point mutation rendering the propeptide protease-resistant | Se-Jin Lee (2008) Genetic analysis of the role of proteolysis in the activation of latent myostatin. PLoS ONE 3(8):e1628. doi:10.1371/journal.pone.0001628 | available |
| Tll2 knockout | deletion of exon 7 | Se-Jin Lee (2008) Genetic analysis of the role of proteolysis in the activation of latent myostatin. PLoS ONE 3(8):e1628. doi:10.1371/journal.pone.0001628 | available |
| Tll1 knockout | unpublished | pending publication | |
| Tll1-flox | unpublished | pending publication | |
| Bmp1 knockout | unpublished | pending publication | |
| Bmp1-flox | unpublished | pending publication | |
| Mstn-flox | unpublished | pending publication | |
| Smad2-flox | unpublished | pending publication | |
| Bmp9 (Gdf2) knockout | deletion of C-terminal domain | unpublished | pending publication |
| Inhbc knockout | deletion of C-terminal domain | unpublished | pending publication |
| Inhbe (Gdf12) knockout | deletion of C-terminal domain | unpublished | pending publication |
| Inhbc/Inhbedouble knockout | deletion of entire Inhbc/Inhbelocus | Se-Jin Lee, Yun-Sil Lee, Teresa A. Zimmers, Arshia Soleimani, Martin M. Matzuk, Kunihiro Tsuchida, Ronald D. Cohn, and Elisabeth R. Barton (2010) Regulation of muscle mass by follistatin and activins. Mol. Endocrinol.24:1998-2008 | available |
| MLC/rtTA MLC/tetR-KRAB | myosin light chain promoter/enhancer | unpublished | pending publication |